CAD (gene)

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Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dihydroorotase domain of human CAD. PDB entry 4c6c[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol CAD
External IDs OMIM114010 HomoloGene1412 GeneCards: CAD Gene
EC number,,
Species Human Mouse
Entrez 790 69719
Ensembl ENSG00000084774 ENSMUSG00000013629
UniProt P27708 Q7TN13
RefSeq (mRNA) NM_004341.3 NM_023525.1
RefSeq (protein) NP_004332.2 NP_076014.1
Location (UCSC) Chr 2:
27.44 – 27.47 Mb
PubMed search [1] [2]
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Symbol CAD
Entrez 790
HUGO 1424
OMIM 114010
RefSeq NM_004341
UniProt P27708
Other data
EC number
Locus Chr. 2 p21

CAD is a gene which encodes several enzymes involved in pyrimidine biosynthesis. De-novo synthesis starts with cytosolic carbamoylphosphate synthetase II which uses glutamine, carbon dioxide and 2 ATP. This enzyme is inhibited by UTP.


  1. ^ Grande-García, A.; Lallous, N.; Díaz-Tejada, C.; Ramón-Maiques, S. (2013). "Structure, Functional Characterization, and Evolution of the Dihydroorotase Domain of Human CAD". Structure 22 (2): 185–98. doi:10.1016/j.str.2013.10.016. PMID 24332717. 

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