CAMK1

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CAMK1
Protein CAMK1 PDB 1a06.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK1, CAMKI, calcium/calmodulin dependent protein kinase I
External IDsMGI: 1098535 HomoloGene: 117458 GeneCards: CAMK1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CAMK1
Genomic location for CAMK1
Band3p25.3Start9,757,347 bp[1]
End9,769,992 bp[1]
RNA expression pattern
PBB GE CAMK1 204392 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003656

NM_133926

RefSeq (protein)

NP_003647
NP_003647.1

NP_598687

Location (UCSC)Chr 3: 9.76 – 9.77 MbChr 6: 113.33 – 113.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.[5][6]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134072 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030272 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR (Sep 1995). "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase". EMBO J. 14 (15): 3679–86. PMC 394442. PMID 7641687.
  6. ^ a b "Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I".

Further reading[edit]

External links[edit]