CAMK2A

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Calcium/calmodulin-dependent protein kinase II alpha
Protein CAMK2A PDB 1hkx.png
PDB rendering based on 1hkx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CAMK2A ; CAMKA
External IDs OMIM114078 MGI88256 HomoloGene56577 ChEMBL: 4147 GeneCards: CAMK2A Gene
EC number 2.7.11.17
Orthologs
Species Human Mouse
Entrez 815 12322
Ensembl ENSG00000070808 ENSMUSG00000024617
UniProt Q9UQM7 P11798
RefSeq (mRNA) NM_015981 NM_001286809
RefSeq (protein) NP_057065 NP_001273738
Location (UCSC) Chr 5:
150.22 – 150.29 Mb
Chr 18:
60.93 – 60.99 Mb
PubMed search [1] [2]

Calcium/calmodulin-dependent protein kinase type II alpha chain (CAMKIIα) is an enzyme that in humans is encoded by the CAMK2A gene.[1][2]

Function[edit]

The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

Interactions[edit]

CAMK2A has been shown to interact with:

References[edit]

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
  2. ^ Lin CR, Kapiloff MS, Durgerian S, Tatemoto K, Russo AF, Hanson P, Schulman H, Rosenfeld MG (Sep 1987). "Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase". Proc Natl Acad Sci U S A 84 (16): 5962–6. doi:10.1073/pnas.84.16.5962. PMC 298983. PMID 3475713. 
  3. ^ "Entrez Gene: CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha". 
  4. ^ Walikonis RS, Oguni A, Khorosheva EM, Jeng CJ, Asuncion FJ, Kennedy MB (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2): 423–33. PMID 11160423. 
  5. ^ Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (Sep 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". J. Neurosci. 22 (18): 7879–91. PMID 12223541. 
  6. ^ Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M (Nov 2003). "CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction". J. Biol. Chem. 278 (45): 44745–52. doi:10.1074/jbc.M303576200. PMID 12933808. 

Further reading[edit]