CAMP responsive element modulator

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CAMP responsive element modulator
Protein CREM PDB 1dh3.png
PDB rendering based on 1dh3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CREM ; CREM-2; ICER; hCREM-2
External IDs OMIM123812 HomoloGene84591 GeneCards: CREM Gene
RNA expression pattern
PBB GE CREM 207630 s at tn.png
PBB GE CREM 209967 s at tn.png
PBB GE CREM 210171 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1390 12916
Ensembl ENSG00000095794 ENSMUSG00000063889
UniProt Q03060 P27699
RefSeq (mRNA) NM_001267562 NM_001110850
RefSeq (protein) NP_001254491 NP_001104320
Location (UCSC) Chr 10:
35.13 – 35.21 Mb
Chr 18:
3.27 – 3.34 Mb
PubMed search [1] [2]

cAMP-responsive element modulator is a protein that in humans is encoded by the CREM gene.[1][2][3]


This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.[3]


CAMP responsive element modulator has been shown to interact with FHL5.[4][5]


  1. ^ Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids Research 20 (22): 6106. doi:10.1093/nar/20.22.6106. PMC 334485. PMID 1461747. 
  2. ^ Masquilier D, Foulkes NS, Mattei MG, Sassone-Corsi P (Nov 1993). "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript". Cell Growth & Differentiation 4 (11): 931–7. PMID 7916662. 
  3. ^ a b "Entrez Gene: CREM cAMP responsive element modulator". 
  4. ^ Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156. 
  5. ^ Fimia GM, De Cesare D, Sassone-Corsi P (Mar 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature 398 (6723): 165–9. doi:10.1038/18237. PMID 10086359. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.