From Wikipedia, the free encyclopedia
Jump to: navigation, search
CAP, adenylate cyclase-associated protein 1 (yeast)
Protein CAP1 PDB 1k8f.png
PDB rendering based on 1k8f.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CAP1 ; CAP; CAP1-PEN
External IDs MGI88262 HomoloGene74572 GeneCards: CAP1 Gene
RNA expression pattern
PBB GE CAP1 213798 s at tn.png
PBB GE CAP1 200625 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10487 12331
Ensembl ENSG00000131236 ENSMUSG00000028656
UniProt Q01518 P40124
RefSeq (mRNA) NM_001105530 NM_001301067
RefSeq (protein) NP_001099000 NP_001287996
Location (UCSC) Chr 1:
40.04 – 40.07 Mb
Chr 4:
122.86 – 122.89 Mb
PubMed search [1] [2]

Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene.[1][2][3]

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin.[3]


CAP1 has been shown to interact with ACTG1[4] and CAP2.[2]


  1. ^ Matviw H, Yu G, Young D (Nov 1992). "Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase-associated CAP proteins". Mol Cell Biol 12 (11): 5033–40. PMC 360436. PMID 1406678. 
  2. ^ a b Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Apr 1997). "Mammalian CAP interacts with CAP, CAP2, and actin". J Cell Biochem 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950. 
  3. ^ a b "Entrez Gene: CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)". 
  4. ^ Hubberstey, A; Yu G; Loewith R; Lakusta C; Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". J. Cell. Biochem. (UNITED STATES) 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. ISSN 0730-2312. PMID 8761950. 

Further reading[edit]