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Calpain 5
Symbols CAPN5 ; ADNIV; HTRA3; VRNI; nCL-3
External IDs OMIM602537 MGI1100859 HomoloGene31212 GeneCards: CAPN5 Gene
RNA expression pattern
PBB GE CAPN5 205166 at tn.png
More reference expression data
Species Human Mouse
Entrez 726 12337
Ensembl ENSG00000149260 ENSMUSG00000035547
UniProt O15484 O08688
RefSeq (mRNA) NM_004055 NM_001301250
RefSeq (protein) NP_004046 NP_001288179
Location (UCSC) Chr 11:
77.07 – 77.13 Mb
Chr 7:
98.12 – 98.18 Mb
PubMed search [1] [2]

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.[1][2][3]

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.[3]


  1. ^ Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024. 
  2. ^ Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857. 
  3. ^ a b "Entrez Gene: CAPN5 calpain 5". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C02.011