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Calpain 9
Protein CAPN9 PDB 1ziv.png
PDB rendering based on 1ziv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CAPN9 ; GC36; nCL-4
External IDs OMIM606401 MGI1920897 HomoloGene38208 GeneCards: CAPN9 Gene
EC number 3.4.22.-
RNA expression pattern
PBB GE CAPN9 210641 at tn.png
PBB GE CAPN9 208063 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10753 73647
Ensembl ENSG00000135773 ENSMUSG00000031981
UniProt O14815 Q9D805
RefSeq (mRNA) NM_006615 NM_023709
RefSeq (protein) NP_006606 NP_076198
Location (UCSC) Chr 1:
230.75 – 230.8 Mb
Chr 8:
124.58 – 124.62 Mb
PubMed search [1] [2]

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.[1][2][3]

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]


  1. ^ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K (May 1998). "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract". Biol Chem 379 (2): 175–184. doi:10.1515/bchm.1998.379.2.175. PMID 9524069. 
  2. ^ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (Jul 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Jpn J Cancer Res 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMID 10835488. 
  3. ^ a b "Entrez Gene: CAPN9 calpain 9". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C02.006