Caspase 14

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Caspase 14, apoptosis-related cysteine peptidase
Symbols CASP14 ; MGC119078; MGC119079
External IDs OMIM605848 MGI1335092 HomoloGene36304 ChEMBL: 5991 GeneCards: CASP14 Gene
EC number 3.4.22.-
Species Human Mouse
Entrez 23581 12365
Ensembl ENSG00000105141 ENSMUSG00000005355
UniProt P31944 O89094
RefSeq (mRNA) NM_012114 NM_009809
RefSeq (protein) NP_036246 NP_033939
Location (UCSC) Chr 19:
15.05 – 15.06 Mb
Chr 10:
78.71 – 78.72 Mb
PubMed search [1] [2]

Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene.[1][2][3]

The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.[3]


  1. ^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P (May 1999). "Identification of a new caspase homologue: caspase-14". Cell Death Differ 5 (10): 838–46. doi:10.1038/sj.cdd.4400444. PMID 10203698. 
  2. ^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM (Dec 1998). "Caspase-14 is a novel developmentally regulated protease". J Biol Chem 273 (45): 29648–53. doi:10.1074/jbc.273.45.29648. PMID 9792675. 
  3. ^ a b "Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase". 

See also[edit]

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: C14.018