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Description carbohydrate-active enzymes database
Research center AFMB, French National Centre for Scientific Research
Laboratory Glycogenomics group
Primary citation Lombard & al. (2014)[1]

CAZy is a database of Carbohydrate-Active enZYmes (CAZymes).[1][2] The database contains a classification and associated information about enzymes involved in the synthesis, metabolism, and transport of carbohydrates. Included in the database are glycoside hydrolases, glycosyltransferases, polysaccharide lyases, carbohydrate esterase and carbohydrate-binding families.

CAZy was established in 1999 in order to provide online and constantly updated access to the family classification of CAZymes.[1] New genomes are added shortly after they appear in the daily releases of GenBank.[3] As of November 2013, CAZy contains sequence information on nearly 340,000 CAZymes.[1]

The CAZy database is coupled with the CAZypedia online encyclopedia, which was launched in June 2009 and intended to be a wiki-based encyclopedia of CAZymes.[4][5] As of 2014, CAZy is developed by the Glycogenomics group at AFMB, a research centre affiliated with the French National Centre for Scientific Research and Aix-Marseille University.[6][7]


CAZy identifies evolutionarily related families of glycosyl hydrolases using the classification introduced by Bernard Henrissat.[8][9] As of 2012 CAZy contains 131 families of glycosyl hydrolase families. These families are given a number to identify them, so for example Glycosyl hydrolase family 1 contains enzymes that possess a TIM barrel fold. These families are clustered into 14 different clans that share structural similarity. CAZy contains 94 families of Glycosyl transferase enzymes,[10] 22 families of polysaccharide lysases[11] and 16 families of carbohydrate esterases.


  1. ^ a b c d Lombard, V.; Golaconda Ramulu, H.; Drula, E.; Coutinho, P. M.; Henrissat, B. (21 November 2013). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (D1): D490–D495. doi:10.1093/nar/gkt1178. PMC 3965031Freely accessible. PMID 24270786. 
  2. ^ Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B (January 2009). "The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics". Nucleic Acids Res. 37 (Database issue): D233–8. doi:10.1093/nar/gkn663. PMC 2686590Freely accessible. PMID 18838391. 
  3. ^ "Home". Retrieved 3 September 2014. 
  4. ^ "About". Retrieved 3 September 2014. 
  5. ^ "History". Retrieved 3 September 2014. 
  6. ^ "About". Retrieved 3 September 2014. 
  7. ^ "AFMB UMR 7257 - UMR7257 : CNRS - AIX MARSEILLE UNIV". Retrieved 3 September 2014. 
  8. ^ Henrissat, B. (1991). "A classification of glycosyl hydrolases based on amino acid sequence similarities". The Biochemical Journal. 280 (Pt 2): 309–316. doi:10.1042/bj2800309. PMC 1130547Freely accessible. PMID 1747104. 
  9. ^ Henrissat, B.; Davies, G. (1997). "Structural and sequence-based classification of glycoside hydrolases". Current Opinion in Structural Biology. 7 (5): 637–644. doi:10.1016/S0959-440X(97)80072-3. PMID 9345621. 
  10. ^ Coutinho, P. M.; Deleury, E.; Davies, G. J.; Henrissat, B. (2003). "An evolving hierarchical family classification for glycosyltransferases". Journal of Molecular Biology. 328 (2): 307–317. doi:10.1016/S0022-2836(03)00307-3. PMID 12691742. 
  11. ^ Lombard, V.; Bernard, T.; Rancurel, C.; Brumer, H.; Coutinho, P. M.; Henrissat, B. (2010). "A hierarchical classification of polysaccharide lyases for glycogenomics". Biochemical Journal. 432 (3): 437–444. doi:10.1042/BJ20101185. PMID 20925655. 

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