CBLC

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CBLC
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CBLC, CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDs MGI: 1931457 HomoloGene: 8108 GeneCards: CBLC
RNA expression pattern
PBB GE CBLC 220638 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130852
NM_012116

NM_001161844
NM_023224

RefSeq (protein)

NP_001124324
NP_036248

NP_075713.3
NP_001155316
NP_075713

Location (UCSC) Chr 19: 44.78 – 44.8 Mb Chr 7: 19.78 – 19.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.[3][4][5]

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM][5]

Interactions[edit]

CBLC has been shown to interact with FYN[6] and Epidermal growth factor receptor.[4][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357. 
  4. ^ a b Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044. 
  5. ^ a b "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c". 
  6. ^ Kim, M; Tezuka T; Suziki Y; Sugano S; Hirai M; Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. NETHERLANDS. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044. 
  7. ^ Keane, M M; Ettenberg S A; Nau M M; Banerjee P; Cuello M; Penninger J; Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. ENGLAND. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357. 

External links[edit]

Further reading[edit]