CBR3

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CBR3
Protein CBR3 PDB 2hrb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDs MGI: 1309992 HomoloGene: 20332 GeneCards: CBR3
RNA expression pattern
PBB GE CBR3 205379 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001236

NM_173047

RefSeq (protein)

NP_001227

NP_766635.1
NP_766635

Location (UCSC) Chr 21: 36.13 – 36.15 Mb Chr 16: 93.68 – 93.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.[3][4][5]

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676. 
  4. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1-3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744Freely accessible. PMID 19027726. 
  5. ^ a b "Entrez Gene: CBR3 carbonyl reductase 3". 

External links[edit]

Further reading[edit]