CBX7 (gene)

CBX7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K1B, 2L12, 2L1B, 3GS2, 4MN3, 5EPJ
Identifiers
Aliases	CBX7, chromobox 7
External IDs	OMIM: 608457 MGI: 1196439 HomoloGene: 65296 GeneCards: CBX7
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,152,680 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,855,320 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; Brodmann area 10; ; frontal pole; ; gastric mucosa; ; middle frontal gyrus; ; pons; ; right coronary artery; ; popliteal artery; ; parietal lobe; ; postcentral gyrus;
	Top expressed in
	yolk sac; ; spermatocyte; ; cerebellar cortex; ; superior frontal gyrus; ; lip; ; cerebellar vermis; ; thymus; ; subcutaneous adipose tissue; ; habenula; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; methylated histone binding; chromatin binding; single-stranded RNA binding;
Cellular component	PcG protein complex; nucleus; nucleoplasm; cytosol; PRC1 complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; chromatin organization; sebaceous gland development;
	Sources:Amigo / QuickGO
Orthologs
	23492
	52609
	ENSG00000100307
	ENSMUSG00000053411
	O95931
	Q8VDS3
	NM_175709; NM_001346743; NM_001346744
	NM_144811
	NP_001333672; NP_001333673; NP_783640; NP_783640.1
	NP_659060
	Wikidata
View/Edit Human	View/Edit Mouse

Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene.^[5] The loss of CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100307 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053411 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Chromobox homolog 7". Retrieved 2011-12-06.
^ Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, et al. (August 2008). "Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer". Cancer Research. 68 (16): 6770–8. doi:10.1158/0008-5472.CAN-08-0695. PMID 18701502.

Further reading[edit]

Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. (June 2010). "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a". Molecular Cell. 38 (5): 662–74. doi:10.1016/j.molcel.2010.03.021. PMC 2886305. PMID 20541999.
Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M, et al. (September 2009). "Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein". Cancer Research. 69 (17): 7079–87. doi:10.1158/0008-5472.CAN-09-1542. PMID 19706751.
Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, et al. (August 2010). "The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients". European Journal of Cancer. 46 (12): 2304–13. doi:10.1016/j.ejca.2010.05.011. PMID 20542683.
Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, et al. (August 2010). "Oncogenic role of the chromobox protein CBX7 in gastric cancer". Journal of Experimental & Clinical Cancer Research. 29 (1): 114. doi:10.1186/1756-9966-29-114. PMC 2933612. PMID 20723236.
Hu CK, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Alvarado AS, Brunet A (February 2020). "Vertebrate diapause preserves organisms long term through Polycomb complex members". Science. 367 (6480): 870–874. Bibcode:2020Sci...367..870H. doi:10.1126/science.aaw2601. PMC 7532943. PMID 32079766.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100307 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053411 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Chromobox homolog 7". Retrieved 2011-12-06.

[6] Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, et al. (August 2008). "Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer". Cancer Research. 68 (16): 6770–8. doi:10.1158/0008-5472.CAN-08-0695. PMID 18701502.

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