CBY1

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CBY1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CBY1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1, chibby homolog 1 (Drosophila), chibby family member 1, beta catenin antagonist
External IDs MGI: 1920989 HomoloGene: 12514 GeneCards: CBY1
RNA expression pattern
PBB GE CBY1 203450 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015373
NM_001002880

NM_028634

RefSeq (protein)

NP_001002880
NP_056188

NP_082910.1
NP_082910

Location (UCSC) Chr 22: 38.66 – 38.67 Mb Chr 15: 79.66 – 79.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.[3][4][5]

Function[edit]

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[5]

Interactions[edit]

CBY1 has been shown to interact with Beta-catenin.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  4. ^ Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699. 
  5. ^ a b "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)". 
  6. ^ Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206. 

External links[edit]

Further reading[edit]