CCBP2

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ACKR2
Identifiers
Aliases ACKR2, CCBP2, CCR10, CCR9, CMKBR9, D6, hD6, atypical chemokine receptor 2
External IDs MGI: 1891697 HomoloGene: 992 GeneCards: ACKR2
RNA expression pattern
PBB GE CCBP2 206887 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001296

NM_001276719
NM_021609

RefSeq (protein)

NP_001287

NP_001263648.1
NP_067622.2
NP_001263648
NP_067622

Location (UCSC) Chr 3: 42.8 – 42.89 Mb Chr 9: 121.9 – 121.91 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[3][4][5]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936. 
  4. ^ Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Jan 1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404. 
  5. ^ a b "Entrez Gene: CCBP2 chemokine binding protein 2". 

Further reading[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.