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Atypical chemokine receptor 2
Symbols ACKR2 ; CCBP2; CCR10; CCR9; CMKBR9; D6; hD6
External IDs OMIM602648 MGI1891697 HomoloGene992 IUPHAR: 314 GeneCards: ACKR2 Gene
RNA expression pattern
PBB GE CCBP2 206887 at tn.png
More reference expression data
Species Human Mouse
Entrez 1238 59289
Ensembl ENSG00000144648 ENSMUSG00000044534
UniProt O00590 O08707
RefSeq (mRNA) NM_001296 NM_001276719
RefSeq (protein) NP_001287 NP_001263648
Location (UCSC) Chr 3:
42.8 – 42.89 Mb
Chr 9:
121.9 – 121.91 Mb
PubMed search [1] [2]

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[1][2][3]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[3]


  1. ^ Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936. 
  2. ^ Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Jan 1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404. 
  3. ^ a b "Entrez Gene: CCBP2 chemokine binding protein 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.