CCL12

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Ccl12
Identifiers
Aliaseschemokine (C-C motif) ligand 12MCP-5Scya12
External IDsHomoloGene: 2245 GeneCards: [1]
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)
Genomic location for Ccl12
Genomic location for Ccl12
Band11 C|11 49.9 cMStart82,101,845 bp
End82,103,400 bp
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011331

n/a

RefSeq (protein)

NP_035461

n/a

Location (UCSC)Chr 11: 82.1 – 82.1 Mbn/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes.[2] This chemokine is found predominantly in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.[2][3] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ a b Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med. 184 (5): 1939–51. doi:10.1084/jem.184.5.1939. PMC 2192876Freely accessible. PMID 8920881. 
  3. ^ a b Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med. 185 (1): 99–109. doi:10.1084/jem.185.1.99. PMC 2196097Freely accessible. PMID 8996246.