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chemokine (C-C motif) ligand 16
Symbol CCL16
Alt. symbols SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1
Entrez 6360
HUGO 10614
OMIM 601394
RefSeq NM_004590
UniProt O15467
Other data
Locus Chr. 17 q11.2

Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes.[1] Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. Its gene is located on chromosome 17, in humans, among a cluster of other CC chemokines.[2] CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8.[3][4]


  1. ^ Youn et al. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem. Biophys. Res. Commun. 247:217-222 (1998).
  2. ^ Nomiyama et al. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. J. Interferon Cytokine Res. 19:227-234 (1999).
  3. ^ Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.
  4. ^ Howard et al. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood. 2000 Aug 1;96(3):840-5.