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Available structures
PDB Ortholog search: PDBe RCSB
Aliases CCL21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine ligand 21
External IDs OMIM: 602737 MGI: 1349183 HomoloGene: 2247 GeneCards: 6366
RNA expression pattern
PBB GE CCL21 204606 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 34.71 – 34.71 Mb Chr 4: 42.77 – 42.77 Mb
PubMed search [1] [2]
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Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).[3][4][5] The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hedrick JA, Zlotnik A (1997). "Identification and characterization of a novel beta chemokine containing six conserved cysteines". J. Immunol. 159 (4): 1589–93. PMID 9257816. 
  4. ^ Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (1997). "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension". J. Immunol. 159 (6): 2554–8. PMID 9300671. 
  5. ^ Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". J. Biol. Chem. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955. 
  6. ^ Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O (1998). "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7". J. Biol. Chem. 273 (12): 7118–22. doi:10.1074/jbc.273.12.7118. PMID 9507024. 

Further reading[edit]