CCL3

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For the aerodrome using the TC LID, CCL3, see Christina Lake Aerodrome.
CCL3
Protein CCL3 PDB 1b50.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
External IDs OMIM: 182283 HomoloGene: 88430 GeneCards: 6348
RNA expression pattern
PBB GE CCL3 205114 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002983

n/a

RefSeq (protein)

NP_002974.1

n/a

Location (UCSC) Chr 17: 36.09 – 36.09 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[1]

Function[edit]

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes[2] through binding to the receptors CCR1, CCR4 and CCR5.[1]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[3][1]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[4]

Interactions[edit]

CCL3 has been shown to interact with CCL4.[5] Attracts macrophages, monocytes and neutrophils.

See also[edit]

References[edit]

  1. ^ a b c "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3". 
  2. ^ Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154. 
  3. ^ Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856. 
  4. ^ Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science (New York, N.Y.) 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711. 
  5. ^ Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300. 

Further reading[edit]

  • Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480. 
  • Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381. 
  • Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726. 
  • Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175. 
  • Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. PMID 15817944. 
  • Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research 15 (11-12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.