CCL4

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CCL4
Protein CCL4 PDB 1hum.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4, C-C motif chemokine ligand 4
External IDs OMIM: 182284 MGI: 98261 HomoloGene: 48153 GeneCards: CCL4
RNA expression pattern
PBB GE CCL4 204103 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002984

NM_013652

RefSeq (protein)

NP_002975

NP_038680.1
NP_038680

Location (UCSC) Chr 17: 36.1 – 36.11 Mb Chr 11: 83.66 – 83.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.[3]

Function[edit]

CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.[4]

CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.[5]

Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.[6]

Interactions[edit]

CCL4 has been shown to interact with CCL3.[7]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932Freely accessible. PMID 1972563. 
  4. ^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nat. Immunol. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067. 
  5. ^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. doi:10.1126/science.270.5243.1811. PMID 8525373. 
  6. ^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage inflammatory protein-1β". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9283–8. doi:10.1073/pnas.161298998. PMC 55412Freely accessible. PMID 11470920. 
  7. ^ Guan, E; Wang J; Norcross M A (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". J. Biol. Chem. United States. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. ISSN 0021-9258. PMID 11278300. 

External links[edit]

Further reading[edit]