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For carbon tetrachloride, with formula CCl4, see Carbon tetrachloride.
Chemokine (C-C motif) ligand 4
Protein CCL4 PDB 1hum.png
PDB rendering based on 1hum.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CCL4 ; ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4
External IDs OMIM182284 MGI98261 HomoloGene48153 GeneCards: CCL4 Gene
RNA expression pattern
PBB GE CCL4 204103 at tn.png
More reference expression data
Species Human Mouse
Entrez 6351 20303
Ensembl ENSG00000275302 ENSMUSG00000018930
UniProt P13236 P14097
RefSeq (mRNA) NM_002984 NM_013652
RefSeq (protein) NP_002975 NP_038680
Location (UCSC) Chr 17:
36.1 – 36.11 Mb
Chr 11:
83.66 – 83.66 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.[1]


CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.[2]

CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.[3]

Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.[4]


CCL4 has been shown to interact with CCL3.[5]

See also[edit]


  1. ^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Res. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563. 
  2. ^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nat. Immunol. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067. 
  3. ^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science 270 (5243): 1811–5. doi:10.1126/science.270.5243.1811. PMID 8525373. 
  4. ^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage inflammatory protein-1β". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9283–8. doi:10.1073/pnas.161298998. PMC 55412. PMID 11470920. 
  5. ^ Guan, E; Wang J; Norcross M A (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". J. Biol. Chem. (United States) 276 (15): 12404–9. doi:10.1074/jbc.M006327200. ISSN 0021-9258. PMID 11278300. 

Further reading[edit]