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Chemokine (C-C motif) ligand 7
Protein CCL7 PDB 1bo0.png
PDB rendering based on 1bo0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CCL7 ; FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7
External IDs OMIM158106 MGI99512 HomoloGene4568 GeneCards: CCL7 Gene
RNA expression pattern
PBB GE CCL7 208075 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6354 20306
Ensembl ENSG00000108688 ENSMUSG00000035373
UniProt P80098 Q03366
RefSeq (mRNA) NM_006273 NM_013654
RefSeq (protein) NP_006264 NP_038682
Location (UCSC) Chr 17:
34.27 – 34.27 Mb
Chr 11:
82.05 – 82.05 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function[citation needed]. It is produced by certain tumor cell lines and by macrophages.[1] This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines[2] and is most closely related to CCL2 (previously called MCP1).


CCL7 has been shown to interact with MMP2.[3]


  1. ^ Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Biochem. Biophys. Res. Commun. 191 (2): 535–42. doi:10.1006/bbrc.1993.1251. PMID 8461011. 
  2. ^ Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328. 
  3. ^ McQuibban, G A; Gong J H; Tam E M; McCulloch C A; Clark-Lewis I; Overall C M (August 2000). "Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3". Science (UNITED STATES) 289 (5482): 1202–6. doi:10.1126/science.289.5482.1202. ISSN 0036-8075. PMID 10947989. 

Further reading[edit]