CCNDBP1

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CCNDBP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CCNDBP1, DIP1, GCIP, HHM, cyclin D1 binding protein 1
External IDs MGI: 109595 HomoloGene: 7826 GeneCards: CCNDBP1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012142
NM_037370

NM_010761

RefSeq (protein)

NP_036274

NP_034891.2
NP_034891

Location (UCSC) Chr 15: 43.19 – 43.2 Mb Chr 2: 121.01 – 121.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.[3][4]

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.[4]

Interactions[edit]

CCNDBP1 has been shown to interact with GRAP2[5] and Cyclin D1.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Aug 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J Biol Chem. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854. 
  4. ^ a b "Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1". 
  5. ^ Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J. Biol. Chem. UNITED STATES. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. ISSN 0021-9258. PMID 10801854. 

External links[edit]

Further reading[edit]