Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1gene.
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.
^ abXia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Aug 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J Biol Chem. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID10801854.
^Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J. Biol. Chem. UNITED STATES. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. ISSN0021-9258. PMID10801854.
Ma W, Xia X, Stafford LJ, et al. (2006). "Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis.". Oncogene. 25 (30): 4207–16. doi:10.1038/sj.onc.1209450. PMID16501603.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Terai S, Aoki H, Ashida K, Thorgeirsson SS (2000). "Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression". Hepatology. 32 (2): 357–66. doi:10.1053/jhep.2000.9092. PMID10915743.
Yamada S, Iida T, Tabata T, et al. (2000). "Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat". Hepatology. 32 (2): 278–88. doi:10.1053/jhep.2000.9604. PMID10915734.
Yao Y, Doki Y, Jiang W, et al. (2000). "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins". Exp. Cell Res. 257 (1): 22–32. doi:10.1006/excr.2000.4884. PMID10854051.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.