CCR9

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CCR9
Identifiers
AliasesCCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28, C-C motif chemokine receptor 9
External IDsOMIM: 604738 MGI: 1341902 HomoloGene: 22546 GeneCards: CCR9
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CCR9
Genomic location for CCR9
Band3p21.31Start45,886,504 bp[1]
End45,903,175 bp[1]
RNA expression pattern
PBB GE CCR9 207445 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256369
NM_006641
NM_031200

NM_001166625
NM_009913

RefSeq (protein)

NP_001243298
NP_006632
NP_112477

NP_001160097
NP_034043

Location (UCSC)Chr 3: 45.89 – 45.9 MbChr 9: 123.68 – 123.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.[5][6]

CCR9 has also recently been designated CDw199 (cluster of differentiation w199).

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in thymocyte recruitment and development that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173585 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029530 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G (Jun 1999). "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK". J Immunol. 162 (10): 5671–5. PMID 10229797.
  6. ^ a b "Entrez Gene: CCR9 chemokine (C-C motif) receptor 9".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.