CCT5 (gene)

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CCT5
5uyz.jpg
Identifiers
Aliases CCT5, CCT-epsilon, CCTE, HEL-S-69, TCP-1-epsilon, PNAS-102, chaperonin containing TCP1 subunit 5
External IDs MGI: 107185 HomoloGene: 6287 GeneCards: CCT5
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CCT5
Genomic location for CCT5
Band 5p15.2 Start 10,249,921 bp[1]
End 10,266,412 bp[1]
RNA expression pattern
PBB GE CCT5 208696 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001306153
NM_001306154
NM_001306155
NM_001306156
NM_012073

NM_007637
NM_001348035

RefSeq (protein)

NP_001293082
NP_001293083
NP_001293084
NP_001293085
NP_036205

NP_001334964
NP_031663

Location (UCSC) Chr 5: 10.25 – 10.27 Mb Chr 15: 31.59 – 31.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

T-complex protein 1 subunit epsilon is a protein that in humans is encoded by the CCT5 gene.[5]

Function[edit]

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[5]

Interactions[edit]

CCT5 (gene) has been shown to interact with PPP4C.[6][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150753 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022234 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)". 
  6. ^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017Freely accessible. PMID 18715871. 
  7. ^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. 

External links[edit]

Further reading[edit]