Poliovirus receptor-related 2

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  (Redirected from CD112)
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NECTIN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDsMGI: 97822 HomoloGene: 86092 GeneCards: NECTIN2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NECTIN2
Genomic location for NECTIN2
Band19q13.32Start44,846,175 bp[1]
End44,889,228 bp[1]
RNA expression pattern
PBB GE PVRL2 203149 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042724
NM_002856

NM_001159724
NM_008990

RefSeq (protein)

NP_001036189
NP_002847

NP_001153196
NP_033016

Location (UCSC)Chr 19: 44.85 – 44.89 MbChr 7: 19.72 – 19.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.[5]

Function[edit]

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130202 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062300 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.