CD11a

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ITGAL
Protein ITGAL PDB 1cqp.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITGAL, CD11A, LFA-1, LFA1A, integrin subunit alpha L
External IDs MGI: 96606 HomoloGene: 1666 GeneCards: ITGAL
Gene location (Human)
Chromosome 16 (human)
Chr. Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ITGAL
Genomic location for ITGAL
Band 16p11.2 Start 30,472,658 bp[1]
End 30,523,185 bp[1]
RNA expression pattern
PBB GE ITGAL 213475 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001114380
NM_002209

NM_001253872
NM_001253873
NM_001253874
NM_008400

RefSeq (protein)

NP_001107852
NP_002200

NP_001240801
NP_001240802
NP_001240803
NP_032426

Location (UCSC) Chr 16: 30.47 – 30.52 Mb Chr 16: 127.3 – 127.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.

Function[edit]

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.[5]

CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Efalizumab acts as an immunosuppressant by binding to CD11a but was withdrawn in 2009 because it was associated with severe side effects.

Interactions[edit]

CD11a has been shown to interact with ICAM-1.[6][7][8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000005844 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030830 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)". 
  6. ^ Lu C, Takagi J, Springer TA (May 2001). "Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state". J. Biol. Chem. 276 (18): 14642–8. PMID 11279101. doi:10.1074/jbc.M100600200. 
  7. ^ Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA (Jan 2003). "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation". Cell. 112 (1): 99–111. PMID 12526797. doi:10.1016/S0092-8674(02)01257-6. 
  8. ^ Yusuf-Makagiansar H, Makagiansar IT, Hu Y, Siahaan TJ (Dec 2001). "Synergistic inhibitory activity of alpha- and beta-LFA-1 peptides on LFA-1/ICAM-1 interaction". Peptides. 22 (12): 1955–62. PMID 11786177. doi:10.1016/S0196-9781(01)00546-0. 

Further reading[edit]

External links[edit]