CD11c

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ITGAX
Protein ITGAX PDB 1n3y.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITGAX, CD11C, SLEB6, integrin subunit alpha X
External IDs OMIM: 151510 MGI: 96609 HomoloGene: 55493 GeneCards: 3687
RNA expression pattern
PBB GE ITGAX 210184 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000887
NM_001286375

NM_021334

RefSeq (protein)

NP_000878.2
NP_001273304.1

NP_067309.1

Location (UCSC) Chr 16: 31.36 – 31.38 Mb Chr 7: 128.13 – 128.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .[3][4]

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[3]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.