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tumor necrosis factor receptor superfamily, member 1A
Alt. symbols CD120a, TNFR1
Entrez 7132
HUGO 11916
OMIM 191190
RefSeq NM_001065
UniProt P19438
Other data
Locus Chr. 12 p13.2
tumor necrosis factor receptor superfamily, member 1B
Alt. symbols CD120a, TNFR2
Entrez 7133
HUGO 11917
OMIM 191191
RefSeq NM_001066
UniProt P20333
Other data
Locus Chr. 1 p36.22

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]

Receptor subtypes[edit]

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a - TNFR1 - TNFR superfamily member 1A
  • CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]

Signaling pathway[edit]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

See also[edit]


  1. ^ Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407. 
  2. ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693. 
  3. ^ Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology (Berl.) 201 (4): 549–56. doi:10.1007/s00213-008-1331-4. PMC 2711641. PMID 18825372. 
  4. ^ McCoy MK, Tansey MG (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation 5 (1): 45. doi:10.1186/1742-2094-5-45. PMC 2577641. PMID 18925972. 
  5. ^ Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord 11 (7): 726–34. doi:10.1111/j.1399-5618.2009.00757.x. PMID 19839997. 

External links[edit]