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Tumor necrosis factor receptor superfamily, member 9
Symbols TNFRSF9 ; 4-1BB; CD137; CDw137; ILA
External IDs OMIM602250 MGI1101059 HomoloGene1199 GeneCards: TNFRSF9 Gene
RNA expression pattern
PBB GE TNFRSF9 207536 s at tn.png
PBB GE TNFRSF9 211786 at tn.png
More reference expression data
Species Human Mouse
Entrez 3604 21942
Ensembl ENSG00000049249 ENSMUSG00000028965
UniProt Q07011 P20334
RefSeq (mRNA) NM_001561 NM_001077508
RefSeq (protein) NP_001552 NP_001070976
Location (UCSC) Chr 1:
7.92 – 7.94 Mb
Chr 4:
150.91 – 150.95 Mb
PubMed search [1] [2]

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.


CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Specific effects on cells[edit]

The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.


CD137 has been shown to interact with TRAF2.[1][2]

See also[edit]


  1. ^ Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS (Jan 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B". Biochem. Biophys. Res. Commun. 242 (3): 613–20. doi:10.1006/bbrc.1997.8016. PMID 9464265. 
  2. ^ Arch RH, Thompson CB (Jan 1998). "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB". Mol. Cell. Biol. 18 (1): 558–65. PMC 121523. PMID 9418902. 

Further reading[edit]