From Wikipedia, the free encyclopedia
Jump to: navigation, search
CD151 molecule (Raph blood group)
Symbols CD151 ; GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24
External IDs OMIM602243 MGI1096360 HomoloGene20916 GeneCards: CD151 Gene
RNA expression pattern
PBB GE CD151 204306 s at tn.png
More reference expression data
Species Human Mouse
Entrez 977 12476
Ensembl ENSG00000177697 ENSMUSG00000025510
UniProt P48509 O35566
RefSeq (mRNA) NM_001039490 NM_001111049
RefSeq (protein) NP_001034579 NP_001104519
Location (UCSC) Chr 11:
0.83 – 0.84 Mb
Chr 7:
141.47 – 141.47 Mb
PubMed search [1] [2]

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[1]


The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[1]


Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.[2]

See also[edit]


  1. ^ a b "Entrez Gene: CD151 CD151 molecule (Raph blood group)". 
  2. ^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.