CD151

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CD151
Identifiers
Aliases CD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group)
External IDs OMIM: 602243 MGI: 1096360 HomoloGene: 20916 GeneCards: 977
RNA expression pattern
PBB GE CD151 204306 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139030
NM_001039490
NM_004357
NM_139029

NM_001111049
NM_001111050
NM_009842

RefSeq (protein)

NP_001104519.1
NP_001104520.1
NP_033972.2

Location (UCSC) Chr 11: 0.83 – 0.84 Mb Chr 7: 141.47 – 141.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[3]

Function[edit]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[3]

Interactions[edit]

Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: CD151 CD151 molecule (Raph blood group)". 
  4. ^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.