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CD177 molecule
Symbols CD177 ; HNA-2a; HNA2A; NB1; NB1 GP; PRV-1; PRV1
External IDs OMIM162860 MGI1916141 HomoloGene49628 GeneCards: CD177 Gene
Species Human Mouse
Entrez 57126 68891
Ensembl ENSG00000204936 ENSMUSG00000052212
UniProt Q8N6Q3 Q8R2S8
RefSeq (mRNA) NM_020406 NM_026862
RefSeq (protein) NP_065139 NP_081138
Location (UCSC) Chr 19:
43.35 – 43.36 Mb
Chr 7:
24.74 – 24.76 Mb
PubMed search [1] [2]

CD177 antigen is a protein that in humans is encoded by the CD177 gene.[1][2][3]

NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971).[supplied by OMIM][3]

See also[edit]


  1. ^ Temerinac S, Klippel S, Strunck E, Roder S, Lubbert M, Lange W, Azemar M, Meinhardt G, Schaefer HE, Pahl HL (May 2000). "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera". Blood 95 (8): 2569–76. PMID 10753836. 
  2. ^ Lalezari P, Murphy GB, Allen FH Jr (Jun 1971). "NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia". J Clin Invest 50 (5): 1108–15. doi:10.1172/JCI106582. PMC 292033. PMID 5552408. 
  3. ^ a b "Entrez Gene: CD177 CD177 molecule". 

Further reading[edit]

  • Stroncek D (2003). "Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology". Vox Sang. 83 Suppl 1: 359–61. doi:10.1111/j.1423-0410.2002.tb05334.x. PMID 12617169. 
  • Pahl HL (2003). "PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera". Curr. Hematol. Rep. 2 (3): 231–6. PMID 12901344. 
  • Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213. 
  • Goldschmeding R, van Dalen CM, Faber N et al. (1992). "Further characterization of the NB 1 antigen as a variably expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and specific granules of neutrophils". Br. J. Haematol. 81 (3): 336–45. doi:10.1111/j.1365-2141.1992.tb08237.x. PMID 1382544. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Stroncek DF, Herr GP, Plachta LB (1994). "Neutrophil-specific antigen NB1 inhibits neutrophil-endothelial cell interactions". J. Lab. Clin. Med. 123 (2): 247–55. PMID 8301201. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Kissel K, Santoso S, Hofmann C et al. (2001). "Molecular basis of the neutrophil glycoprotein NB1 (CD177) involved in the pathogenesis of immune neutropenias and transfusion reactions". Eur. J. Immunol. 31 (5): 1301–9. doi:10.1002/1521-4141(200105)31:5<1301::AID-IMMU1301>3.0.CO;2-J. PMID 11465086. 
  • Bettinotti MP, Olsen A, Stroncek D (2002). "The use of bioinformatics to identify the genomic structure of the gene that encodes neutrophil antigen NB1, CD177". Clin. Immunol. 102 (2): 138–44. doi:10.1006/clim.2001.5154. PMID 11846455. 
  • Kissel K, Scheffler S, Kerowgan M, Bux J (2002). "Molecular basis of NB1 (HNA-2a, CD177) deficiency". Blood 99 (11): 4231–3. doi:10.1182/blood.V99.11.4231. PMID 12010833. 
  • Klippel S, Strunck E, Busse CE et al. (2002). "Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera". Blood 100 (7): 2441–8. doi:10.1182/blood-2002-03-0949. PMID 12239154. 
  • Teofili L, Martini M, Luongo M et al. (2002). "Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia". J. Clin. Oncol. 20 (20): 4249–54. doi:10.1200/JCO.2002.11.507. PMID 12377969. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Najfeld V, Fuchs S, Merando P et al. (2003). "Fluorescence in situ hybridization analysis of the PRV-1 gene in polycythemia vera: implications for its role in diagnosis and pathogenesis". Exp. Hematol. 31 (2): 118–21. doi:10.1016/S0301-472X(02)01032-9. PMID 12591276. 
  • Wolff J, Brendel C, Fink L et al. (2003). "Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms". Blood 102 (2): 731–3. doi:10.1182/blood-2002-09-2831. PMID 12623849. 
  • Johansson P, Andréasson B, Safai-Kutti S et al. (2003). "The presence of a significant association between elevated PRV-1 mRNA expression and low plasma erythropoietin concentration in essential thrombocythaemia". Eur. J. Haematol. 70 (6): 358–62. doi:10.1034/j.1600-0609.2003.00079.x. PMID 12756017. 

External links[edit]