CD180

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CD180
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD180, LY64, Ly78, RP105, CD180 molecule
External IDsMGI: 1194924 HomoloGene: 4077 GeneCards: CD180
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CD180
Genomic location for CD180
Band5q12.3Start67,179,613 bp[1]
End67,196,799 bp[1]
RNA expression pattern
PBB GE CD180 206206 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005582

NM_008533
NM_001360519

RefSeq (protein)

NP_005573

NP_032559
NP_001347448

Location (UCSC)Chr 5: 67.18 – 67.2 MbChr 13: 102.69 – 102.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD180 antigen is a protein that in humans is encoded by the CD180 gene.[5][6][7][8]

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134061 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021624 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–22. PMID 9763566. 
  6. ^ Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706. 
  7. ^ a b "Entrez Gene: CD180 CD180 molecule". 
  8. ^ [4]

External links[edit]

Further reading[edit]