CD1A

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CD1A
Protein CD1A PDB 1onq.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCD1A, CD1, FCB6, HTA1, R4, T6, CD1a molecule
External IDsOMIM: 188370 HomoloGene: 113556 GeneCards: CD1A
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD1A
Genomic location for CD1A
Band1q23.1Start158,254,424 bp[1]
End158,258,269 bp[1]
RNA expression pattern
PBB GE CD1A 210325 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001763
NM_001320652

n/a

RefSeq (protein)

NP_001307581
NP_001754

n/a

Location (UCSC)Chr 1: 158.25 – 158.26 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene.[3]

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[3]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158477 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: CD1A CD1a molecule".

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.