This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID17077296.
Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.". Hum. Mol. Genet. 1 (8): 613–20. doi:10.1093/hmg/1.8.613. PMID1301170.
Aruffo A, Seed B (1989). "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.". J. Immunol. 143 (5): 1723–30. PMID2701945.
Longley J, Kraus J, Alonso M, Edelson R (1989). "Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.". J. Invest. Dermatol. 92 (4): 628–31. doi:10.1111/1523-1747.ep12712175. PMID2784820.