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CD1a molecule
Protein CD1A PDB 1onq.png
PDB rendering based on 1onq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD1A ; CD1; FCB6; HTA1; R4; T6
External IDs OMIM188370 HomoloGene113556 GeneCards: CD1A Gene
RNA expression pattern
PBB GE CD1A 210325 at tn.png
More reference expression data
Species Human Mouse
Entrez 909 n/a
Ensembl ENSG00000158477 n/a
UniProt P06126 n/a
RefSeq (mRNA) NM_001763 n/a
RefSeq (protein) NP_001754 n/a
Location (UCSC) Chr 1:
158.25 – 158.26 Mb
PubMed search [1] n/a

CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene.[1]

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.