CD1D

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CD1D
Protein CD1D PDB 1zt4.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD1D, CD1A, R3, R3G1, CD1d molecule
External IDs OMIM: 188410 MGI: 107674 HomoloGene: 1337 GeneCards: CD1D
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD1D
Genomic location for CD1D
Band 1q23.1 Start 158,179,947 bp[1]
End 158,184,896 bp[1]
RNA expression pattern
PBB GE CD1D 205789 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001766
NM_001319145

NM_007639

RefSeq (protein)

NP_001306074
NP_001757

NP_031665

Location (UCSC) Chr 1: 158.18 – 158.18 Mb Chr 1: 87 – 87 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD1D is the human gene that encodes the protein CD1d,[5] a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.

Biological significance[edit]

CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes.[5] When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.

Nomenclature[edit]

CD1d is also known as R3G1

Ligands[edit]

Some of the known ligands for CD1d are:

CD1d tetramers[edit]

CD1d tetramers are protein constructs composed of four CD1d molecules joined together and usually fluorescently labelled, used to identify NKT cells or other CD1d-reactive cells. In particular, type I NKT cells and some type II NKT cells are stained by them. A differentiation of these two types can be obtained in human by using an antibody against the TCR Vα24 chain, which is specific of type I NKT cells.[10]

Although they are the most widely used of CD1d oligomers, sometimes CD1d dimers (two units) or pentamers (five units) are used instead.[10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158473 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028076 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "P15813 (CD1D_HUMAN)". Uniprot. Retrieved 1 March 2013. 
  6. ^ Franck, Richard W. (1 January 2012). "C-Galactosylceramide: Synthesis and Immunology". C R Chim. 15 (1): 46–56. PMC 3293403Freely accessible. PMID 22408579. doi:10.1016/j.crci.2011.05.006. 
  7. ^ Bendelac, A; Savage PB; Teyton I (2007). "The Biology of NKT Cells". Annual Review of Immunology. 25 (1): 297–336. PMID 17150027. doi:10.1146/annurev.immunol.25.022106.141711. 
  8. ^ Zhou, D (August 2006). "The immunological function of iGb3". Current Protein & Peptide Science. 7 (4): 325–33. PMID 16918447. doi:10.2174/138920306778018007. 
  9. ^ J. Kerzerho; E. Yu; C. M. Barra; E. Alari-Pahissa; E. Girardi; Y. Harrak; P. Lauzurica; A. Llebaria; D. Zajonc; O. Akbari; A. R. Castaño (2012). "Structural and functional characterization of a novel non-glycosidic iNKT agonist with immunomodulatory properties". Journal of Immunology. 188: 2254–2265. PMC 3288653Freely accessible. PMID 22301545. doi:10.4049/jimmunol.1103049. 
  10. ^ a b Terabe, Masaki; Berzofsky, Jay A. (2008). "The Role of NKT Cells in Tumor Immunity". Adv Cancer Res. 101: 277–348. PMC 2693255Freely accessible. PMID 19055947. doi:10.1016/S0065-230X(08)00408-9. 

Further reading[edit]

External links[edit]