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CD1d molecule
Protein CD1D PDB 1zt4.png
PDB rendering based on 1zt4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD1D ; CD1A; R3
External IDs OMIM188410 MGI107674 HomoloGene1337 ChEMBL: 1649053 GeneCards: CD1D Gene
RNA expression pattern
PBB GE CD1D 205789 at tn.png
More reference expression data
Species Human Mouse
Entrez 912 12479
Ensembl ENSG00000158473 ENSMUSG00000028076
UniProt P15813 P11609
RefSeq (mRNA) NM_001766 NM_007639
RefSeq (protein) NP_001757 NP_031665
Location (UCSC) Chr 1:
158.18 – 158.18 Mb
Chr 3:
87 – 87 Mb
PubMed search [1] [2]

CD1D is the human gene that encodes the protein CD1d,[1] a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are non-classical MHC proteins, related to the class I MHC proteins, and are involved in the presentation of lipid antigens to T cells. CD1d is the only member of the group 2 CD1 molecules.

Biological significance[edit]

CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes.[1] When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production.


CD1d is also known as R3G1


Some of the known ligands for CD1d are:

CD1d tetramers[edit]

CD1d tetramers are protein constructs composed of four CD1d molecules joined together and usually fluorescently labelled, used to identify NKT cells or other CD1d-reactive cells. In particular, type I NKT cells and some type II NKT cells are stained by them. A differentiation of these two types can be obtained in human by using an antibody against the TCR Vα24 chain, which is specific of type I NKT cells.[6]

Although they are the most widely used of CD1d oligomers, sometimes CD1d dimers (two units) or pentamers (five units) are used instead.[6]


  1. ^ a b "P15813 (CD1D_HUMAN)". Uniprot. Retrieved 1 March 2013. 
  2. ^ Franck, Richard W. (1 January 2012). "C-Galactosylceramide: Synthesis and Immunology". C R Chim. 15 (1): 46–56. doi:10.1016/j.crci.2011.05.006. PMC 3293403. PMID 22408579. 
  3. ^ Bendelac, A; Savage PB; Teyton I (2007). "The Biology of NKT Cells". Annual Review of Immunology 25 (1): 297–336. doi:10.1146/annurev.immunol.25.022106.141711. PMID 17150027. 
  4. ^ Zhou, D (August 2006). "The immunological function of iGb3". Current Protein & Peptide Science 7 (4): 325–323. doi:10.2174/138920306778018007. PMID 16918447. Retrieved 4 March 2013. 
  5. ^ J. Kerzerho, E. Yu, C. M. Barra, E. Alari-Pahissa, E. Girardi, Y. Harrak, P. Lauzurica, A. Llebaria, D. Zajonc, O. Akbari, A. R. Castaño (2012). "Structural and functional characterization of a novel non-glycosidic iNKT agonist with immunomodulatory properties". Journal of Immunology 188: 2254–2265. doi:10.4049/jimmunol.1103049. PMID 22301545. 
  6. ^ a b Terabe, Masaki; Berzofsky, Jay A. (2008). "The Role of NKT Cells in Tumor Immunity". Adv Cancer Res 101: 277–348. doi:10.1016/S0065-230X(08)00408-9. PMC 2693255. PMID 19055947. Retrieved 8 March 2013. 

Further reading[edit]

External links[edit]