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CD207 molecule, langerin
Protein CD207 PDB 3C22.png
Rendering based on PDB 3C22.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD207 ; CLEC4K
External IDs OMIM604862 MGI2180021 HomoloGene9252 GeneCards: CD207 Gene
RNA expression pattern
PBB GE CD207 220428 at tn.png
More reference expression data
Species Human Mouse
Entrez 50489 246278
Ensembl ENSG00000116031 ENSMUSG00000034783
UniProt Q9UJ71 Q8VBX4
RefSeq (mRNA) NM_015717 NM_144943
RefSeq (protein) NP_056532 NP_659192
Location (UCSC) Chr 2:
70.83 – 70.84 Mb
Chr 6:
83.67 – 83.68 Mb
PubMed search [1] [2]

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[1][2] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.[2][3]


The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[1]

Clinical significance[edit]

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[4][5]

See also[edit]


  1. ^ a b EntrezGene 50489
  2. ^ a b Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances Vé, Vincent C, Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407. 
  3. ^ Valladeau J, Clair-Moninot Vé, Dezutter-Dambuyant C, Pin J-J, Kissenpfennig A, Mattéi M-G, Ait-Yahia S, Bates EEM, Malissen B (2002). "Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues". Journal of Immunology 168 (2): 782–92. doi:10.4049/jimmunol.168.2.782. PMID 11777972. 
  4. ^ De Witte L, Nabatov A, Pion M, Fluitsma D, De Jong MAWP, De Gruijl T, Piguet V, Van Kooyk Y, Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373. 
  5. ^ Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". Journal of Leukocyte Biology 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229. 

Further reading[edit]

External links[edit]