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CD226 molecule
Symbols CD226 ; DNAM-1; DNAM1; PTA1; TLiSA1
External IDs OMIM605397 MGI3039602 HomoloGene4787 GeneCards: CD226 Gene
RNA expression pattern
PBB GE CD226 207315 at tn.png
More reference expression data
Species Human Mouse
Entrez 10666 225825
Ensembl ENSG00000150637 ENSMUSG00000034028
UniProt Q15762 Q8K4F0
RefSeq (mRNA) NM_001303618 NM_001039148
RefSeq (protein) NP_001290547 NP_001034238
Location (UCSC) Chr 18:
69.83 – 69.96 Mb
Chr 18:
89.2 – 89.27 Mb
PubMed search [1] [2]

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')[1] or DNAM-1 (DNAX Accessory Molecule-1)[1] is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.[2]

Structure and function[edit]

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,[3][4] and cross-linking CD226 with antibodies causes cellular activation.[2]

See also[edit]


  1. ^ a b Fuchs, Anja; Colonna, M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340. 
  2. ^ a b "Entrez Gene: CD226 CD226 molecule". 
  3. ^ Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096. 
  4. ^ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.