CD24

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CD24
Identifiers
AliasesCD24, CD24A, CD24 molecule
External IDsOMIM: 600074 GeneCards: CD24
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CD24
Genomic location for CD24
Band6q21Start106,969,831 bp[1]
End106,975,627 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291737
NM_001291738
NM_001291739
NM_013230
NM_001359084

n/a

RefSeq (protein)

NP_001278666
NP_001278667
NP_001278668
NP_037362
NP_001346013

n/a

Location (UCSC)Chr 6: 106.97 – 106.98 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.[3] CD24 is a cell adhesion molecule.

Function[edit]

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils[4] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.[5] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,[6] and this appears to be defective in sepsis.[6] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined (source: NCBI).

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000272398 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics. 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762. 
  4. ^ Elghetany MT, Patel J (December 2002). "Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development". American Journal of Hematology. 71 (4): 348–9. doi:10.1002/ajh.10176. PMID 12447971. 
  5. ^ Gilliam DT, Menon V, Bretz NP, Pruszak J (March 2017). "The CD24 surface antigen in neural development and disease". Neurobiology of Disease. 99: 133–144. doi:10.1016/j.nbd.2016.12.011. PMID 27993646. 
  6. ^ a b Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon JM (March 2014). "CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis". Journal of Immunology. 192 (5): 2449–59. doi:10.4049/jimmunol.1301055. PMID 24501201. 

Further reading[edit]

External links[edit]