CD244

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CD244
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 molecule
External IDsMGI: 109294 HomoloGene: 9493 GeneCards: CD244
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD244
Genomic location for CD244
Band1q23.3Start160,830,160 bp[1]
End160,862,855 bp[1]
RNA expression pattern
PBB GE CD244 220307 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166663
NM_001166664
NM_016382

NM_018729

RefSeq (protein)

NP_001160135
NP_001160136
NP_057466

NP_061199

Location (UCSC)Chr 1: 160.83 – 160.86 MbChr 1: 171.56 – 171.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[5] It is also known as Natural Killer Cell Receptor 2B4[6]

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7] CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.[8]


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