CD244

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Not to be confused with KIR2DL4.
CD244
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 molecule
External IDs MGI: 109294 HomoloGene: 9493 GeneCards: 51744
RNA expression pattern
PBB GE CD244 220307 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166663
NM_001166664
NM_016382

NM_018729

RefSeq (protein)

NP_001160135.1
NP_001160136.1
NP_057466.1

NP_061199.2

Location (UCSC) Chr 1: 160.83 – 160.86 Mb Chr 1: 171.56 – 171.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[1] It is also known as Natural Killer Cell Receptor 2B4[2]

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3] CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.[4]


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