IL2RA

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IL2RA
Protein IL2RA PDB 1z92.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs MGI: 96549 HomoloGene: 360 GeneCards: IL2RA
RNA expression pattern
PBB GE IL2RA 211269 s at fs.png

PBB GE IL2RA 206341 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000417
NM_001308242
NM_001308243

NM_008367

RefSeq (protein)

NP_000408
NP_001295171
NP_001295172

NP_032393

Location (UCSC) Chr 10: 6.01 – 6.06 Mb Chr 2: 11.64 – 11.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.[3]

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.[4]

Description[edit]

It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes. Though IL2RA has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large proportion of resting memory T cells constitutively express IL2RA in humans.[5]

IL2RA is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, mastocytosis and tumor infiltrating lymphocytes. It functions as the receptor for HTLV-1 and is consequently expressed on neoplastic cells in adult T cell lymphoma/leukemia. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.

Clinical significance[edit]

Chagas disease[edit]

Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.

Multiple sclerosis[edit]

The multiple sclerosis drug daclizumab binds to and blocks IL2RA.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Leonard WJ, Donlon TA, Lebo RV, Greene WC (Aug 1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science. 228 (4707): 1547–9. PMID 3925551. doi:10.1126/science.3925551. 
  4. ^ "Entrez Gene: IL2RA interleukin 2 receptor, alpha". 
  5. ^ Triplett, Todd A.; et al. (July 2012). "Defining a functionally distinct subset of human memory CD4+ T cells that are CD25POS and FOXP3NEG". European Journal of Immunology. 42 (7): 1893. PMID 22585674. doi:10.1002/eji.201242444. 
  6. ^ "Zinbryta Summary of Product Characteristics" (PDF). European Medicines Agency. 2016. 

Further reading[edit]

External links[edit]