CD276

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CD276
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, CD276 molecule
External IDs MGI: 2183926 HomoloGene: 11892 GeneCards: CD276
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024736
NM_025240
NM_001329628
NM_001329629

NM_133983

RefSeq (protein)

NP_001019907
NP_001316557
NP_001316558
NP_079516

NP_598744

Location (UCSC) Chr 15: 73.68 – 73.71 Mb Chr 9: 58.52 – 58.56 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.[3]

Function[edit]

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM][3]

CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.[4]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]