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CD276 molecule
Symbols CD276 ; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2
External IDs OMIM605715 MGI2183926 HomoloGene11892 GeneCards: CD276 Gene
Species Human Mouse
Entrez 80381 102657
Ensembl ENSG00000103855 ENSMUSG00000035914
UniProt Q5ZPR3 Q8VE98
RefSeq (mRNA) NM_001024736 NM_133983
RefSeq (protein) NP_001019907 NP_598744
Location (UCSC) Chr 15:
73.68 – 73.71 Mb
Chr 9:
58.52 – 58.56 Mb
PubMed search [1] [2]

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.[1]

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM][1]

CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.[2]

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