CD32

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
SymbolFCGR2A
Alt. symbolsFCG2, FCGR2A1, FCGR2
NCBI gene2212
HGNC3616
OMIM146790
RefSeqNM_021642
UniProtP12318
Other data
LocusChr. 1 q23
Fc fragment of IgG, low affinity IIb, receptor (CD32)
CD32ray.png
Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).[1]
Identifiers
SymbolFCGR2B
Alt. symbolsFCG2, FCGR2
NCBI gene2213
HGNC3618
OMIM604590
RefSeqNM_004001
UniProtP31994
Other data
LocusChr. 1 q23
Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Identifiers
SymbolFCGR2C
NCBI gene9103
HGNC15626
RefSeqNM_201563
UniProtP31995
Other data
LocusChr. 1 q23

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.[2]

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body. Monoclonal antibodies can distinguish between CD32A and CD32B.[3]

References[edit]

  1. ^ PDB: 2FCB​; Sondermann P, Huber R, Jacob U (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution". The EMBO Journal. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577.; rendered via PyMOL.
  2. ^ Anania JC, Chenoweth AM, Wines BD, Hogarth PM (2019). "The Human FcγRII (CD32) Family of Leukocyte FcR in Health and Disease". Frontiers in Immunology. 10: 464. doi:10.3389/fimmu.2019.00464. PMC 6433993. PMID 30941127.
  3. ^ Veri MC, Gorlatov S, Li H, Burke S, Johnson S, Stavenhagen J, et al. (July 2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology. 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.

External links[edit]