T-cell surface glycoprotein CD3 epsilon chain

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Protein CD3E PDB 1xiw.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CD3E, IMD18, T3E, TCRE, CD3e molecule
External IDs MGI: 88332 HomoloGene: 586 GeneCards: CD3E
RNA expression pattern
PBB GE CD3E 205456 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 118.3 – 118.32 Mb Chr 9: 45 – 45.01 Mb
PubMed search [1] [2]
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CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.[3][4]


The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.[5]

Clinical significance[edit]

Defects in this gene cause severe immunodeficiency.[6][7] This gene has also been linked to a susceptibility to type I diabetes in women.[8]


T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,[9] CD3EAP[10] and NCK2.[11]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature. 321 (6068): 431–4. PMID 3012357. doi:10.1038/321431a0. 
  4. ^ Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8156–60. PMC 282386Freely accessible. PMID 3267235. doi:10.1073/pnas.85.21.8156. 
  5. ^ "Entrez Gene: CD3E CD3e molecule, epsilon (CD3-TCR complex)". 
  6. ^ Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B (January 1993). "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency". Nature Genetics. 3 (1): 77–81. PMID 8490660. doi:10.1038/ng0193-77. 
  7. ^ de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F (November 2004). "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3". The Journal of Clinical Investigation. 114 (10): 1512–7. PMC 525745Freely accessible. PMID 15546002. doi:10.1172/JCI22588. 
  8. ^ Wong S, Moore S, Orisio S, Millward A, Demaine AG (January 1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11". Clinical and Experimental Immunology. 83 (1): 69–73. PMC 1535466Freely accessible. PMID 1671006. doi:10.1111/j.1365-2249.1991.tb05590.x. 
  9. ^ Nakano H, Yamazaki T, Miyatake S, Nozaki N, Kikuchi A, Saito T (March 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". The Journal of Biological Chemistry. 271 (11): 6483–9. PMID 8626450. doi:10.1074/jbc.271.11.6483. 
  10. ^ Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (June 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". The Journal of Biological Chemistry. 274 (26): 18173–80. PMID 10373416. doi:10.1074/jbc.274.26.18173. 
  11. ^ Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B (June 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell. 109 (7): 901–12. PMID 12110186. doi:10.1016/S0092-8674(02)00799-7. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.