CD247

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CD247
Protein CD247 PDB 2hac.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD247, CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ, CD247 molecule
External IDs MGI: 88334 HomoloGene: 12818 GeneCards: CD247
Genetically Related Diseases
systemic scleroderma, rheumatoid arthritis, celiac disease[1]
RNA expression pattern
PBB GE CD247 210031 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000734
NM_198053

NM_001113391
NM_001113392
NM_001113393
NM_001113394
NM_031162

RefSeq (protein)

NP_000725.1
NP_932170.1

NP_112439.1
NP_001106862.1
NP_001106862.1
NP_112439.1

Location (UCSC) Chr 1: 167.43 – 167.52 Mb Chr 1: 165.79 – 165.88 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.[4]

Genomics[edit]

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function[edit]

T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[5]

Interactions[edit]

CD247 has been shown to interact with Janus kinase 3[6] and Protein unc-119 homolog.[7]

See also[edit]

References[edit]

  1. ^ "Diseases that are genetically associated with CD247 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. doi:10.1073/pnas.85.24.9709. PMC 282845Freely accessible. PMID 2974162. 
  5. ^ "Entrez Gene: CD247 CD247 molecule". 
  6. ^ Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123. 
  7. ^ Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793Freely accessible. PMID 14757743. 

Further reading[edit]

External links[edit]