Integrin alpha 1

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ITGA1
Protein ITGA1 PDB 1ck4.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGA1, CD49a, VLA1, integrin subunit alpha 1
External IDsOMIM: 192968 MGI: 96599 HomoloGene: 57137 GeneCards: ITGA1
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ITGA1
Genomic location for ITGA1
Band5q11.2Start52,787,896 bp[1]
End52,959,210 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181501

NM_001033228

RefSeq (protein)

NP_852478

NP_001028400

Location (UCSC)Chr 5: 52.79 – 52.96 MbChr 13: 114.95 – 115.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213949 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042284 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: ITGA1 integrin, alpha 1".

Further reading[edit]

External links[edit]