CD49a

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ITGA1
Protein ITGA1 PDB 1ck4.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITGA1, CD49a, VLA1, integrin subunit alpha 1
External IDs OMIM: 192968 MGI: 96599 HomoloGene: 57137 GeneCards: 3672
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181501

NM_001033228

RefSeq (protein)

NP_852478.1

NP_001028400.2

Location (UCSC) Chr 5: 52.79 – 52.96 Mb Chr 13: 114.96 – 115.1 Mb
PubMed search [1] [2]
Wikidata
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CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[1]

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