CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49bgene.
The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells.
^Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem.276 (31): 29375–81. doi:10.1074/jbc.M102217200. PMID11359774.
^Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem.276 (31): 29368–74. doi:10.1074/jbc.M104179200. PMID11359786.
Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.". Italian Heart Journal4 (1): 17–22. PMID12690916.
Tsantes AE, Nikolopoulos GK, Bagos PG, Vaiopoulos G, Travlou A (2007). "Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis.". Int. J. Cardiol.118 (2): 189–96. doi:10.1016/j.ijcard.2006.06.047. PMID17023078.