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Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ITGA4 ; CD49D; IA4
External IDs OMIM192975 MGI96603 HomoloGene37364 ChEMBL: 278 GeneCards: ITGA4 Gene
RNA expression pattern
PBB GE ITGA4 213416 at tn.png
PBB GE ITGA4 205884 at tn.png
PBB GE ITGA4 205885 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3676 16401
Ensembl ENSG00000115232 ENSMUSG00000027009
UniProt P13612 Q00651
RefSeq (mRNA) NM_000885 NM_010576
RefSeq (protein) NP_000876 NP_034706
Location (UCSC) Chr 2:
181.46 – 181.54 Mb
Chr 2:
79.26 – 79.33 Mb
PubMed search [1] [2]

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.


The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.[1]


CD49d has been shown to interact with LGALS8[2] and Paxillin.[3][4]


  1. ^ "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". 
  2. ^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. 113 (Pt 13): 2385–97. PMID 10852818. 
  3. ^ Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025. 
  4. ^ Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182. 

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