Integrin alpha 4

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ITGA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGA4, CD49D, IA4, integrin subunit alpha 4
External IDsOMIM: 192975 MGI: 96603 HomoloGene: 37364 GeneCards: ITGA4
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ITGA4
Genomic location for ITGA4
Band2q31.3Start181,457,202 bp[1]
End181,536,187 bp[1]
RNA expression pattern
PBB GE ITGA4 205884 at fs.png

PBB GE ITGA4 205885 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000885
NM_001316312

NM_010576

RefSeq (protein)

NP_000876
NP_001303241

NP_034706

Location (UCSC)Chr 2: 181.46 – 181.54 MbChr 2: 79.26 – 79.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

Function[edit]

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.[5]

Interactions[edit]

CD49d has been shown to interact with LGALS8[6] and Paxillin.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115232 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027009 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)". 
  6. ^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (Pt 13): 2385–97. PMID 10852818. 
  7. ^ Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025. 
  8. ^ Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182. 

Further reading[edit]

External links[edit]