CD6

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CD6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD6, TP120, CD6 molecule
External IDsOMIM: 186720 MGI: 103566 HomoloGene: 4893 GeneCards: CD6
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CD6
Genomic location for CD6
Band11q12.2Start60,971,680 bp[1]
End61,020,377 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001254750
NM_001254751
NM_006725

NM_001037801
NM_009852

RefSeq (protein)

NP_001241679
NP_001241680
NP_006716

NP_001032890
NP_033982

Location (UCSC)Chr 11: 60.97 – 61.02 MbChr 19: 10.79 – 10.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[5][6]

Function[edit]

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.[5]

Clinical significance[edit]

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.[7][8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000013725 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024670 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: CD6 CD6 molecule". 
  6. ^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054Freely accessible. PMID 7760007. 
  7. ^ De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet. 41 (7): 776–82. doi:10.1038/ng.401. PMC 2757648Freely accessible. PMID 19525953. 
  8. ^ Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation". J. Immunol. 187 (6): 3286–91. doi:10.4049/jimmunol.1100626. PMID 21849685. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.