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CD69 molecule
Protein CD69 PDB 1e87.png
PDB rendering based on 1e87.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD69 ; AIM; BL-AC/P26; CLEC2C; EA1; GP32/28; MLR-3
External IDs OMIM107273 MGI88343 HomoloGene128584 GeneCards: CD69 Gene
RNA expression pattern
PBB GE CD69 209795 at tn.png
More reference expression data
Species Human Mouse
Entrez 969 12515
Ensembl ENSG00000110848 ENSMUSG00000030156
UniProt Q07108 P37217
RefSeq (mRNA) NM_001781 NM_001033122
RefSeq (protein) NP_001772 NP_001028294
Location (UCSC) Chr 12:
9.75 – 9.76 Mb
Chr 6:
129.27 – 129.28 Mb
PubMed search [1] [2]

CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene.

The activation of T lymphocytes and Natural Killer (NK) Cells, both in vivo and in vitro, induces expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, including natural killer (NK) cells, and platelets (Cambiaggi et al., 1992) [supplied by OMIM].[1]

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