CD7

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CD7
Identifiers
Aliases CD7, GP40, LEU-9, TP41, Tp40, CD7 molecule
External IDs MGI: 88344 HomoloGene: 4471 GeneCards: CD7
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CD7
Genomic location for CD7
Band 17q25.3 Start 82,314,868 bp[1]
End 82,317,602 bp[1]
RNA expression pattern
PBB GE CD7 214551 s at fs.png

PBB GE CD7 214049 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006137

NM_009854

RefSeq (protein)

NP_006128

NP_033984

Location (UCSC) Chr 17: 82.31 – 82.32 Mb Chr 17: 121.04 – 121.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[5]

Function[edit]

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[5]

See also[edit]

Interactions[edit]

CD7 has been shown to interact with PIK3R1.[6][7]

Clinical significance[edit]

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[8] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173762 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025163 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: CD7 CD7 molecule". 
  6. ^ Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8): 1195–203. PMID 8918688. doi:10.1093/intimm/8.8.1195. 
  7. ^ Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". European Journal of Immunology. 33 (1): 46–52. PMID 12594831. doi:10.1002/immu.200390006. 
  8. ^ Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F (October 2012). "Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study". Leukemia Research. 36 (10): 1229–36. PMID 22682984. doi:10.1016/j.leukres.2012.05.006. 
  9. ^ Stevens SR, Baron ED, Masten S, Cooper KD (October 2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Archives of Dermatology. 138 (10): 1347–50. PMID 12374541. doi:10.1001/archderm.138.10.1347. 

Further reading[edit]

External links[edit]