CD79A

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CD79a molecule, immunoglobulin-associated alpha
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CD79A ; IGA; MB-1
External IDs OMIM112205 MGI101774 HomoloGene31053 GeneCards: CD79A Gene
RNA expression pattern
PBB GE CD79A 205049 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 973 12518
Ensembl ENSG00000105369 ENSMUSG00000003379
UniProt P11912 P11911
RefSeq (mRNA) NM_001783 NM_007655
RefSeq (protein) NP_001774 NP_031681
Location (UCSC) Chr 19:
42.38 – 42.39 Mb
Chr 7:
24.9 – 24.9 Mb
PubMed search [1] [2]

CD79a molecule, immunoglobulin-associated alpha, also known as mb-1, is a human gene.[1]

The mb-1 gene codes for a phosphoprotein, designated CD79a (cluster of differentiation [CD]79a, that, together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells. The CD79a/CD79b dimer is closely associated with the B-cell antigen receptor, in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface.[2]

It is associated with agammaglobulinemia-3.[citation needed]

Interactions[edit]

CD79A has been shown to interact with B-cell linker[3][4] and Alpha-1-microglobulin/bikunin precursor.[5][6]

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

Diagnostic relevance[edit]

The CD79a protein is present on the surface of B-cells throughout their life cycle, and is absent on all other healthy cells, making it a highly reliable marker for B-cells in immunohistochemistry. The protein remains present when B-cells transform into active plasma cells, and is also present in virtually all B-cell neoplasms, including B-cell lymphomas, plasmacytomas, and myelomas. It is also present in abnormal lymphocytes associated with some cases of Hodgkins disease. Because even on B-cell precursors, it can be used to stain a wider range of cells than can the alternative B-cell marker CD20, but the latter is more commonly retained on mature B-cell lymphomas, so that the two are often used together in immunohistochemistry panels.[2]

References[edit]

  1. ^ a b "Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha". 
  2. ^ a b Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. XX. ISBN 1-84110-100-1. 
  3. ^ Engels, N; Wollscheid B, Wienands J (July 2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha". Eur. J. Immunol. (Germany) 31 (7): 2126–34. doi:10.1002/1521-4141(200107)31:7<2126::AID-IMMU2126>3.0.CO;2-O. ISSN 0014-2980. PMID 11449366. 
  4. ^ Kabak, Shara; Skaggs Brian J, Gold Michael R, Affolter Michael, West Kelly L, Foster Mark S, Siemasko Karyn, Chan Andrew C, Aebersold Ruedi, Clark Marcus R (April 2002). "The Direct Recruitment of BLNK to Immunoglobulin α Couples the B-Cell Antigen Receptor to Distal Signaling Pathways". Mol. Cell. Biol. (United States) 22 (8): 2524–35. doi:10.1128/MCB.22.8.2524-2535.2002. ISSN 0270-7306. PMC 133735. PMID 11909947. 
  5. ^ Grubb, A O; López C, Tejler L, Mendez E (December 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. (UNITED STATES) 258 (23): 14698–707. ISSN 0021-9258. PMID 6196366. 
  6. ^ Berggård, T; Thelin N, Falkenberg C, Enghild J J, Akerström B (May 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. (GERMANY) 245 (3): 676–83. doi:10.1111/j.1432-1033.1997.00676.x. ISSN 0014-2956. PMID 9183005. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.