CD84

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CD84
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD84, LY9B, SLAMF5, hmCD84 molecule
External IDsMGI: 1336885 HomoloGene: 48249 GeneCards: CD84
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD84
Genomic location for CD84
Band1q23.3Start160,541,095 bp[1]
End160,579,516 bp[1]
RNA expression pattern
PBB GE CD84 211190 x at fs.png

PBB GE CD84 211189 x at fs.png

PBB GE CD84 205988 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001184879
NM_001184881
NM_001184882
NM_003874
NM_001330742

NM_001252472
NM_001289470
NM_013489

RefSeq (protein)

NP_001171808
NP_001171810
NP_001171811
NP_001317671
NP_003865

NP_001239401
NP_001276399
NP_038517

Location (UCSC)Chr 1: 160.54 – 160.58 MbChr 1: 171.84 – 171.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.[5]

Function[edit]

Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.[5]

Interactions[edit]

CD84 has been shown to interact with SH2D1A.[6][7][8][9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000066294 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038147 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: CD84 CD84 molecule".
  6. ^ Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
  7. ^ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi:10.1182/blood.V97.12.3867. PMID 11389028.
  8. ^ Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
  9. ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". The Journal of Biological Chemistry. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.