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CD84 molecule
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CD84 ; LY9B; SLAMF5; hCD84; mCD84
External IDs OMIM604513 MGI1336885 HomoloGene48249 GeneCards: CD84 Gene
RNA expression pattern
PBB GE CD84 205988 at tn.png
PBB GE CD84 211189 x at tn.png
PBB GE CD84 211190 x at tn.png
More reference expression data
Species Human Mouse
Entrez 8832 12523
Ensembl ENSG00000066294 ENSMUSG00000038147
UniProt Q9UIB8 Q18PI6
RefSeq (mRNA) NM_001184879 NM_001252472
RefSeq (protein) NP_001171808 NP_001239401
Location (UCSC) Chr 1:
160.54 – 160.58 Mb
Chr 1:
171.84 – 171.89 Mb
PubMed search [1] [2]

CD84 (Cluster of Differentiation 84) is a human protein encoded by the CD84 gene.[1]


Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.[supplied by OMIM][1]


CD84 has been shown to interact with SH2D1A.[2][3][4][5]

See also[edit]


  1. ^ a b "Entrez Gene: CD84 CD84 molecule". 
  2. ^ Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397. 
  3. ^ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood 97 (12): 3867–74. doi:10.1182/blood.V97.12.3867. PMID 11389028. 
  4. ^ Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647. 
  5. ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". The Journal of Biological Chemistry 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.